New Materials, Compounds and Applications

Using p-substituted aniline and o-tolidine as starting materials, this effort involved the synthesis of many novel benzamide, sulfonamide and allyl derivatives. Benzamide derivatives (A1–A6) are prepared with 1,4-dioxane as the solvent and 4-chlorobenzoyl chloride as the reagent. In addition to the base triethylamine and the solvent dichloromethane, the reagent p-toluene sulfonyl chloride was utilized in the production of sulfonamide derivatives (B1-B5). The synthesis of allyl derivatives (C1-C3) involved the use of allyl bromide as a reagent, potassium carbonate as a base and acetone and H₂O as solvents. The identity of the synthetic compound was determined using spectroscopic methods such as FT-IR, ¹H-NMR, ¹³C-NMR and mass spectroscopies, physical measurements were used to characterize all of the produced derivatives. In addition, we studied molecular docking and the biological activity of the produced derivatives, which are characterized by antioxidant and anti-breast cancer properties.