Natural bioactive compounds found in foods and as nutraceuticals show promise for supporting liver detoxification and health through their antioxidant, anti-inflammatory and antifibrotic. Compounds like curcumin, silymarin and resveratrol, along with flavonoids, triterpenoids and others, exhibit hepatoprotective effects by acting as antioxidants, anti-inflammatories and antifibrotics. These compounds can help mitigate liver damage caused by various factors, including drug-induced toxicity, alcohol consumption and metabolic disorders. A healthy diet is crucial for managing and improving liver disease. It involves focusing on nutrient-rich foods, limiting harmful substances and maintaining a healthy weight. A balanced diet with plenty of fruits, vegetables, whole grains, lean protein and healthy fats is recommended. Limiting alcohol, processed foods and foods high in sugar, salt and saturated fats is essential. Several bioactive compounds and nutraceuticals show promise in supporting liver health and potentially treating liver conditions like non-alcoholic fatty liver disease (NAFLD). These include silymarin (from milk thistle), curcumin, omega-3 fatty acids, resveratrol and anthocyanins. Additionally, certain foods like coffee, green tea and cruciferous vegetables are linked to liver health benefits, with their respective compounds being studied for their protective effects.