Advances in Biology & Earth Sciences

The effect of five organic compounds: 5-Amino-2'-oxo-2,3-dihydro-1l2-spiro[imidazo[3,2-a]pyridine-7,3'-indoline]-6,8-dicarbonitrile (I), 6'-Amino-5-bromo-2-oxo-1',2',3',4'-tetrahydro-spiro[indoline-3,8'-pyrido[1,2-a]pyrimidine]-7',9'-dicarbonitrile (II), 3'-Acetyl-6'-amino-5-bromo -2'-methyl-2-oxospiro[indoline-3,4'-pyran]-5'-carbonitrile (III), 6'-Amino-2-oxo-1',2',3',4'-tetra-hydrospiro[indoline-3,8'-pyrido[1,2-a]pyrimidine]-7',9'-dicarbonitrile (IV), Ethyl 2'-amino-6'-(chloromethyl)-3'-cyano-2-oxospiro[indoline-3,4'-pyran]-5'-carboxylate (V) on the growth of gram-negative (Acinetobacter baumannii BDU-32, Escherichia coli BDU-12, Klebsiella pneumoniae BDU-44 and Pseudomonas aeruginosa BDU-49) and gram-positive (Bacillus subtilis BDU-50, Bacillus mesentericus BDU-51, Staphylococcus aureus BDU-23)  pathogenic bacteria was studied. It has been shown that all tested organic compounds have different degrees of antibacterial activity. P. aeruginosa and B. mesentericus showed high sensitivity to all tested compounds; E. coli and B. subtilis showed high sensitivity to compounds III and V; S. aureus - to compounds II, III, IV and V. K. pneumonia showed the same low sensitivity to all tested compounds. However, compounds II and III, which had a low minimum inhibitory concentration, turned out to be the most effective.